Sodhi MS, Arranz MJ, Curtis D, Ball DM, Sham P, Roberts GW, Price J, Collier DA, Kerwin RW. Association between clozapine response and allelic variation in the 5-HT2c receptor gene. Neuro Report 1995 7: 169-172.

A cysteine to serine substitution at amino acid 23 in the 5-HT2c receptor gene alters the pharmacological properties of the protein. We investigated this polymorphism in subjects with schizophrenia resistant to conventional neuroleptic drugs, and analysed our data for allelic association between the disease state or clinical response to the atypical antipsychotic drug, clozapine. Ninety percent of subjects who had one or more 5-HT2c ser alleles (19/21) were classified as clozapine responders, compared with 59% (84/141) without this allele (chi-squared=7.7, p=0.005), suggesting that this mutation is a predictor of good response to clozapine. There was no assocation between schizophrenia and the 5-HT2c ser allele, but our results indicate that the 5-HT2c receptor may contain the major site of action through which clozapine mediates its antipsychotic effects.

Dave Curtis publications