Publications by Dave Curtis

Here is a list of my main publications. Most of them have links to abstracts or to their PubMed entry and you may be able to find some of the others by searching PubMed yourself. Alternatively, just look at my Google Scholar page.

  1. Curtis D. A program to draw pedigrees using LINKAGE or LINKSYS data files. Annals of Human Genetics 1990 54: 365-367.

  2. Gurling HMD, Curtis D, Murray RM. Psychological deficit from excessive alcohol consumption: evidence from a cotwin control study. British Journal of Addiction 1991 86: 151-155.

  3. Holmes DS, Brynjolfsson J, Brett P, Curtis D, Petursson H, Sherrington R, Gurling HMD. No evidence for a susceptibility locus to manic depression in the region of the dopamine (D2) receptor gene. British Journal of Psychiatry 1991 158: 635-641.

  4. Curtis D, Gurling HMD. Using a dummy quantitative variable to deal with multiple affection categories in genetic linkage analysis. Annals of Human Genetics 1991 55: 321-327.

  5. Melmer G, Sherrington R, Mankoo B, Kalsi G, Curtis D, Gurling HMD. A cosmid clone for the 5HT1a receptor (HTR1A) reveals a TaqI RFLP which shows tight linkage to DNA loci D5S6, D5S39 and D5S76. Genomics 1991 11: 767-769.

  6. Sherrington R, Melmer G, Dixon M, Curtis D, Mankoo B, Kalsi G, Gurling HMD. Linkage disequilibrium between two highly polymorphic microsatellites. American Journal of Human Genetics 1991 49: 966-971.

  7. Curtis D, Robertson MM, Gurling HMD. Autosomal dominant gene transmission in a large kindred with Gilles de la Tourette syndrome. British Journal of Psychiatry 1992: 160 845-849.

  8. Curtis D, Gurling HMD. A procedure for combining two-point lod scores into a summary multipoint map. Human Heredity 1993 43: 173-185.

  9. Curtis D, Melmer G, Brynjolfsson J, Holmes DS, Brett P, Petursson H, Rifkin L, Murphy P, Sherrington R, Gurling HMD. Genetic linkage analysis of manic depression in Iceland. Journal of the Royal Society of Medicine 1993 86: 506-510.

  10. Cook CCH, Gurling HMD, Curtis D. DOLINK - a computer program to facilitate management of genetic data and analyses. Ann Hum Genet 1993 57: 307-310.

  11. Sherrington R, Mankoo B, Dixon M, Curtis D, Kalsi G, Melmer G, Gurling HMD. Microsatellite polymorphisms for chromosome 5 bands q11.2-q13.3. Human Heredity 1993 43: 197-202.

  12. Curtis D, Brynjolfsson J, Petursson H, Holmes DS, Sherrington R, Brett P, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD. Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). Annals of Human Genetics 1993 57: 27-39.

  13. Whitehouse WP, Rees M, Curtis D, Sundquist A, Parker K, Chung E, Baralle E, Gardiner RM. Linkage analysis of idiopathic generalised epilepsy and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence of an epilepsy locus in the HLA region. Am J Hum Genet 1993 53: 652-662.

  14. Sherrington R, Mankoo B, Attwood J, Kalsi G, Curtis D, Buetow K, Povey S, Gurling HMD. A highly polymorphic microsatellite for the human dopamine (D5) receptor (DRD5) shows tight linkage to the chromosome 4p reference marker RAF1P1. Genomics 1993 18: 423- 425.

  15. Sherrington R, Brynjolfsson J, Curtis D, Moloney E, Rifkin L, Petursson H, Gurling H. A linkage study with the D5 dopamine receptor in Icelandic pedigrees with multiple cases of manic depression. Psychiatric Genetics 1993 3: 241-245.

  16. Lim LCC, Gurling H, Curtis D, Brynjolfsson J, Petursson H, Gill M. Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees. American Journal of Medical Genetics (Neuropsychiatric Genetics) 1993 48: 223-228.

  17. Curtis D, Sham PC. Using risk calculation to implement an extended relative pair analysis. Ann Hum Genet 1994 58: 151-162.

  18. Curtis D. Another procedure for the preliminary ordering of loci based on two point lod scores. Ann Hum Genet 1994 58: 65-75.

  19. Rees M, Curtis D, Parker K, Sundqvist A, Baralle D, Bespalova IN, Burmeister M, Chung E, Gardiner RM, Whitehouse WP. Linkage analysis of idiopathic generalized epilepsy in families of probands with juvenile myoclonic epilepsy and marker loci in the region of EPM-1 on chromosome 21q - Unverricht-Lundborg disease and JME are not allelic variants. Neuropediatrics 1994 25: 20-25.

  20. Doctor RS, Curtis D and Isaacs G. Psychiatric morbidity in policemen and the effect of brief psychotherapeutic intervention - a pilot study. Stress Medicine 1994 10: 151-157.

  21. Gurling HMD, Curtis D, Brynjolfsson J, Moloney E, Rifkin L, Sherrington R. A linkage study of affective disorder with DNA markers for the ABO-AK1-ORM linkage group near the dopamine beta hydroxylase gene. Biol Psychiat 1994 36: 434-442.

  22. Kalsi G, Mankoo BS, Brynjolfsson J, Curtis D, Read T, Murphy P, Sharma T, Petursson H, Gurling HMD. The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. Psychiat Genet 1994 4: 219-27.

  23. Correspondence: Curtis D, Sham PC, Vallada HP. Genetic analysis of complex disease. Nature Genet 1995 9: 13.

  24. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 1995 59: 97-105.

  25. Correspondence: Gurling H, Smyth C, Kalsi G, Moloney E, Rifkin L, O'Neill J, Murphy P, Curtis D, Petursson H, Brynjolfsson J. Linkage findings in bipolar disorder. Nat Genet 1995 10: 8-10.

  26. Letter: Curtis D, Sham PC. A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 1995 56: 811-812.

  27. Brett PM, Curtis D, Robertson MM, Gurling HMD. Exclusion of the 5HT1A serotonin neuroreceptor and tryptophan oxygenase genes in Gilles de la Tourette syndrome. Am J Psych 1995 152: 437-440.

  28. Brett PM, Curtis D, Robertson MM, Gurling HMD. The genetic susceptibility to Gilles de la Tourette syndrome in a large multiply-affected British kindred - linkage analysis excludes a role for the genes coding for the dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase and tyrosine hydroxylase. Biol Psychiatry 1995 37: 533-540.

  29. Kalsi G, Mankoo BS, Curtis D, Brynjolfsson J, Read T, Sharma T, Murphy P, Petursson H, Gurling HMD. Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites. Psychol Med 1995 25: 531-537.

  30. Sham PC, Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 1995 59: 323-336.

  31. Kalsi G, Brynjolfsson J, Butler R, Sherrington R, Curtis D, Sigmundsson T, Read T, Murphy P, Petursson H, Gurling HMD. Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families. Am J Med Genet (Neuropsychiatric Genetics) 1995 60: 298-301.

  32. Kalsi G, Brynjolfsson J, Mankoo BS, Murphy P, Curtis D, Read T, Petursson H, Gurling HMD. Investigation by linkage analysis of the XY pseudoautosomal region in the genetic susceptibility to schizophrenia. Br J Psychiat 1995 167: 390-393.

  33. Correspondence: Gurling H, Kalsi G, Chen AHS, Green M, Butler R, Read T, Murphy P, Curtis D, Sharma T, Petursson H, Brynjolfsson J. Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 1995 11: 234-235.

  34. Curtis D, Sham PC. Model-free linkage analysis using likelihoods. Am J Hum Genet 1995 57: 703-716.

  35. Dawson E, Gill M, Curtis D, Castle D, Hunt N, Murray RM, Powell JF. Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder. Psychiat Genet 1995 5: 177-180.

  36. Correspondence: Curtis D. Euthanasia. Nat Med 1995 1: 849-50.

  37. Lin MW, Curtis D, Williams N, Arranz M, Nanko S, Collier D, McGuffin P, Murray R, Owen M, Gill M, Powell J. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q22. Psychiat Genet 1995 5: 117-126.

  38. Vallada H, Curtis D, Sham PC, Murray RM, McGuffin P, Nanko S, Gill M, Owen M, Collier DA. Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia. Psychiat Genet 1995 5: 127-130.

  39. Sodhi MS, Arranz MJ, Curtis D, Ball DM, Sham P, Roberts GW, Price J, Collier DA, Kerwin RW. Association between clozapine response and allelic variation in the 5-HT2c receptor gene. Neuro Report 1995 7: 169-172.

  40. Correspondence: Curtis D. Defending attacks on statistics. Nat Med 1996 2: 4.

  41. Kalsi G, Sherrington R, Brynjolfsson J, Curtis D, Read T, Murphy P, Petursson H, Gurling H. A linkage study of the DRD5 (D5) dopamine receptor in multiplex Icelandic and English schizophrenia pedigrees. Am J Psych 1996 153: 107-109.

  42. Smyth C, Kalsi G, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Murphy P, Sherrington RS, Petursson H, Gurling HMD. Further tests for linkage at the tyrosine hydroxylase gene locus on chromosome 11p15 in a new sample of British multiplex manic depression (bipolar and unipolar affective disorder) families. Am J Psych 1996 153: 271-274.

  43. Chung E, Curtis D, Chen G, Marsden PA, Twells R, Xu W, Gardiner RM. Genetic evidence for neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosis. Am J Hum Genet 1996 58: 363-370.

  44. Correspondence: Curtis D. Genetic dissection of traits. Nat Genet 1996 12: 356-357.

  45. Correspondence: Curtis D. Cardiovascular disease risks. Nat Med 1996 2: 365-6.

  46. Correspondence: Curtis D. Burying Freud. Lancet 1996.

  47. Curtis D, Sham PC. Population stratifications can cause false positive linkage results if founders are untyped. Ann Hum Genet 1996 60: 261-263.

  48. Vallada H, Craddock N, Vasques L, Curtis D, Kirov G, Lauriano V, Gentil V, Passos-Bueno R, Murray RM, Zatz M, McGuffin P, Powell JF, Gill M, Owen M, Collier DA. Linkage studies in bipolar affective disorder with markers on chromosome 21. J Affect Disord 1996 41: 217-221.

  49. Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Petursson H, Barnard EA, Gurling HM. Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. Am J Psychiatry 1996 153: 1634-1636.

  50. Kunugi H, Curtis D, Vallada HP, Nanko S, Powell JF, Murray RM, McGuffin P, Owen MJ, Gill M, Collier DA. A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families. Schizophr Res 1996 22: 61-68.

  51. Collier DA, Barrett TG, Curtis D, Macleod A, Arranz MJ, Maassen JA, Bundey S. Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity. Am J Hum Genet 1996 59: 855-863.

  52. Cook CC, Palsson G, Turner A, Holmes D, Brett P, Curtis D, Petursson H, Gurling HM. A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism. Br J Psychiatry 1996 169: 243-248.

  53. Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Barnard EA, Petursson H, Gurling HM. Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. Am J Med Genet 1997 74: 50-52.

  54. Smyth C, Kalsi G, Curtis D, Brynjolfsson J, O'Neill J, Rifkin L, Moloney E, Murphy P, Petursson H, Gurling H. Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22. Genomics 1997 39: 271-278.

  55. Editorial: Fleminger S, Curtis D. Prion diseases. Br J Psychiatry 1997 170: 103-105.

  56. Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Petursson H, Barnard EA, Gurling HM. Exclusion of linkage of schizophrenia to the gene for the glutamate GluR5 receptor. Biol Psychiatry 1997 41: 243-245.

  57. Sham PC, Zhao JH, Curtis D. Optimal weighting scheme for affected sib-pair analysis of sibship data. Ann Hum Genet 1997 61: 61-69.

  58. Elmslie V, Rees M, Williamson M, Kerr M, Kjeldsen MJ, Pang KA, Sundqvist A, Richens A, Friis ML, Chadwick D, Covanis A, Santos M, Arzimanoglou A, Panayiotopoulos CP, Curtis D, Whitehouse WP, Gardiner RM. Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. Hum Mol Genet 1997 6: 1329-1334.

  59. McDermott MF, Ramachandran A, Aganna E, Ogunkolade W, Curtis D, Boucher B, Snehelatha C, Hitman GA. Allelic variation in the vitamin D receptor influences susceptibility to insulin-dependent diabetes mellitus in Indian Asians. Diabetologia 1997 40: 971-975.

  60. Curtis D. Use of siblings as controls in case-control association studies. Ann Hum Genet 1997 61: 319-333.

  61. Smyth C, Kalsi, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Murphy P, Petursson H, Gurling H. Test of Xq26.3-28 linkage in bipolar and unipolar families selected for absence of male to male transmission. Br J Psychiat 1997 171: 578-581.

  62. Brett PM, Curtis D, Robertson MM, Gurling HMD. Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome. Biol Psychiat 1997 42: 941-947.

  63. Li T, Vallada H, Curtis D, Arranz M, Xu K, Cai G, Deng H, Liu J, Murray R, Liu X, Collier DA. Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder. Pharmacogenetics 1997 7: 349-353.

  64. Kalsi G, Smyth C, Brynjolfsson J, Sherrington RS, O'Neill J, Curtis D, Rifkin L, Murphy P, Petursson H, Gurling HM. Linkage analysis of manic depression (bipolar affective disorder) in Icelandic and British kindreds using markers on the short arm of chromosome 18. Hum Hered 1997 47: 268-278.

  65. Brett PM, Yiannakou JY, Morris M-A, Vaughan R, Curtis D, Ciclitira PJ. A family linkage study of coeliac disease: failure to replicate positive findings. Ann Hum Genet 1998 62: 25-32.

  66. McDermott MF, McDermott EM, Quane K, Jones LC, Ogunkolade W, Curtis D, Waldron-Lynch F, Phelan M, Hitman GA, Molloy MG, Powell RJ. Exclusion of the familial Mediterranean fever locus as a susceptibility region for autosomal dominant familial Hibernian fever (FHF). J Med Genet 1998 35: 432-4.

  67. Vallada HP, Vasques L, Curtis D, Zatz M, Kirov G, Lauriano V, Gentil V, Murray RM, McGuffin P, Owen M, Gill M, Craddock N, Collier DA. Linkage analysis between bipolar affective disorder and markers on chromosome X. Psychiatr Genet 1998 8: 183-6.

  68. Kalsi G, Curtis D, Brynjolfsson J, Sigmundsson T, Petursson H, Butler R, Read T, Murphy P, Gurling HMD. Tests of linkage, allelic and genotypic association between schizophrenia and the gene for the D3 dopamine receptor, DRD3. Psychiat Genet 1998 8: 187-9.

  69. Curtis D. Chromosome 21 workshop. Am J Med Genet (Neuropsychiat Genet) 1999 88: 272-275.

  70. Yiannakou JY, Brett PM, Morris MA, Curtis D, Mathew C, Vaughan R, Rosen-Bronson S, Ciclitira PJ. Family linkage study of the T-cell receptor genes in coeliac disease. Ital J Gastroenterol Hepatol 1999 31: 198-201.

  71. Brett PM, Yiannakou JY, Morris M-A, Curtis D, Ciclitira PJ. Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease. Ann Hum Genet 1999 63 217-225.

  72. Kalsi G, Mankoo B, Curtis D, Sherrington R, Melmer G Brynjolfsson J, Sigmundsson T, Read T, Murphy P, Petursson H, Gurling H. New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families. Ann Hum Genet 1999 63 235-247.

  73. Curtis D, Zhao JH, Sham PC. Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data. In: Goldin L, Amos CI, Chase GA, Goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks DW, Wijsman EM, and MacCluer JW. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genet Epidemiol 1999 17 S115-S120.

  74. McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Hannesdottir S, Gurling H. Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus which show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder. Psychol Med 1999 29 1449-1454.

  75. Kalsi G, Gamble D, Curtis D, Brynjolfsson J, Sigmundsson T, Butler R, Read T, Murphy P, Petursson H, Gurling HMD. No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11. Psychiat Genet 1999 9 197-199.

  76. Zhao JH, Curtis D, Sham PC. Model-free and permutation analysis for allelic associations. Hum Hered 2000 50 133-139.

  77. Morris MA, Yiannakou JY, King AL, Brett PM, Biagi F, Vaughan R, Curtis D, Ciclitira PJ. Coeliac disease and Down syndrome: associations not due to genetic linkage on chromosome 21. Scand J Gastroenterol 2000 35 177-80.

  78. Sham PC, Lin MW, Zhao JH, Curtis D. Power comparison of parametric and non-parametric linkage tests in small pedigrees. Am J Hum Genet 2000 66 1661-1668.

  79. Sham PC, Zhao JH, Curtis D. The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations. Ann Hum Genet 2000 64 161-169.

  80. Ogunkolade WB, Ramachandran A, McDermott MF, Kumarajeewa TR, Curtis D, Snehalatha C, Mohan V, Cassell PG, Eskdale J, Gallagher G, Hitman GA. Family association studies of markers on chromosome 2q and type 1 diabetes in subjects from south India. Diabetes Metab Res Rev 2000 16 276-80.

  81. Mynett-Johnson L, Kealey C, Claffey E, Curtis D, Bouchier-Hayes L, Powell C, McKeon P. Multimarker haplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder. Am J Med Genet. 2000 96:845-9.

  82. King AL, Yiannakou JY, Brett PM, Curtis D, Morris M-A, Rhodes M, Dearlove AM, Mathew C, Ciclitira PJ.A Genome-Wide Family-Based Linkage Study of Celiac Disease. Ann Hum Genet 2000 64 479-490.

  83. Sham PC, Zhao JH, Waldman I, Curtis D. Should ambiguous trios for the TDT be discarded? Ann Hum Genet 2000 64 575-576.

  84. Gurling HMD, Kalsi G, Brynjolfsson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, Murray KD, McQuillin A, Petursson H, Curtis D. Genome wide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 2001 68 661-673.
    Link to zip file containing full results of this genome scan.

  85. Blaveri E, Kalsi G, Lawrence J, Quested D, Moorey H, Lamb G, Kohen D, Shiwach R, Chowdhury U, Curtis D, McQuillin A, Gramoustianou ES, Gurling HM. Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). Eur J Hum Genet 2001 9 469-72.

  86. King AL, Fraser JS, Moodie SJ, Curtis D, Dearlove AM, Ellis HJ, Rosen-Bronson S, Ciclitira PJ. Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11. Ann Hum Genet 2001 65 377-86.

  87. Curtis D, North BV, Sham PC. Use of an artificial neural network to detect association between a disease and multiple marker genotypes. Ann Hum Genet 2001 65 95-107.

  88. Curtis D, North BV, Sham PC. A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease. Ann Hum Genet. 2001 65:473-81.

  89. King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ. CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families. J Med Genet. 2002 39:51-4.

  90. Cassell PG, Jackson AE, North BV, Evans JC, Syndercombe-Court D, Phillips C, Ramachandran A, Snehalatha C, Gelding SV, Vijayaravaghan S, Curtis D, Hitman GA. Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. Diabetes 2002 51:1622-8.

  91. Taske NL, Williamson MP, Makoff A, Bate L, Curtis D, Kerr M, Kjeldsen MJ, Pang KA, Sundqvist A, Friis ML, Chadwick D, Richens A, Covanis A, Santos M, Arzimanoglou A, Panayiotopoulos CP, Whitehouse WP, Rees M, Gardiner RM. Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14. Epilepsy Res 2002 49:157-72.

  92. McQuillin A, Kalsi G, Moorey H, Lamb G, Mayet S, Quested D, Baker P, Curtis D, Gurling HM. A novel polymorphism in exon 11 of the WKL1 gene, shows no association with schizophrenia. Eur J Hum Genet 2002 10:491-4.

  93. Moodie SJ, Norman PJ, King AL, Fraser JS, Curtis D, Ellis HJ, Vaughan RW, Ciclitira PJ. Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. Eur J Immunogenet 2002 29:287-91.

  94. King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ. CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families. J Med Genet 2002 39:51-4.

  95. Curtis D, North BV, Gurling HM, Blaveri E, Sham PC. A quick and simple method for detecting subjects with abnormal genetic background in case-control samples. Ann Hum Genet 2002 66:235-44.

  96. Letter: North BV, Curtis D, Sham PC. A note on the calculation of empirical P values from Monte Carlo procedures. Am J Hum Genet 2002 71:439-41.

  97. Curtis D, North BV, Sham PC. Extension of conditional model-free likelihood-based linkage analysis to additive and other models. Ann Hum Genet 2002 66:157-67.

  98. Hassan Z, Mohan V, Ali L, Allotey R, Barakat K, Faruque MO, Deepa R, McDermott MF, Jackson AE, Cassell P, Curtis D, Gelding SV, Vijayaravaghan S, Gyr N, Whitcomb DC, Khan AK, Hitman GA. SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. Am J Hum Genet 2002 71:964-8.

  99. Letter: North BV, Curtis D, Sham PC. A note on calculation of empirical P values from Monte Carlo procedures. Am J Hum Genet 2003 72:498-9.

  100. Carbonell J, Allen R, Kalsi G, McQuillin A, Livingston G, Katona C, Walker Z, Katz A, Rands G, Stevens T, Crossan I, Curtis D, Gurling H. Variation in the DCP1 gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer's disease. Psychiatr Genet. 2003 13:47-50.

  101. Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C, Moloney E, Murphy P, McQuillin A, Petursson H, Gurling H. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. Psychiatr Genet. 2003 13:77-84.
    Link to zip file containing full results of this genome scan.

  102. North BV, Curtis D, Cassell PG, Hitman GA, Sham PC. Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes. Ann Hum Genet 2003 67:348-56.

  103. Knight J, North BV, Sham PC, Curtis D. Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait. BMC Genet. 2003 4 Suppl 1:S74.

  104. Sham PC, Rijsdijk FV, Knight J, Makoff A, North B, Curtis D. Haplotype association analysis of discrete and continuous traits using mixture of regression models. Behav Genet 2004 34:207-14.

  105. Curtis D, Brett P, Dearlove AM, McQuillin A, Kalsi G, Robertson MM, Gurling HM. Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13. Psychiatr Genet 2004 14:83-87.

  106. North BV, Curtis D, Martin ER, Lai EH, Roses AD, Sham PC. Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci. Ann Hum Genet 2004 68:240-8.

  107. Curtis D. Re-analysis of collaborative study on the genetics of alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299. Psychiatr Genet. 2004 14:151-5.

  108. Guerrini I, Cook CC, Kest W, Devitgh A, McQuillin A, Curtis D, Gurling HM. Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2. BMC Genet. 2005 Mar 1;6(1):11.

  109. Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H. The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia. Am J Hum Genet. 2005 May;76(5):902-7.

  110. North BV, Curtis D, Sham PC. Application of logistic regression to case-control association studies involving two causative loci. Hum Hered. 2005;59(2):79-87.

  111. Curtis D, Kerr M. NICE recommendations for valproate treatment are unhelpful. Br J Psychiatry. 2005 May;186:447.

  112. Vincent JB, Melmer G, Bolton PF, Hodgkinson S, Holmes D, Curtis D, Gurling HM. Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region. Psychiatr Genet. 2005 Jun;15(2):83-90.

  113. Curtis D, Knight J, Sham PC. A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees. Psychiatr Genet. 2005 Sep;15(3):181-187.

  114. Puri V, McQuillin A, Thirumalai S, Lawrence J, Krasucki R, Choudhury K, Datta S, Kerwin S, Quested D, Bass N, Pimm J, Lamb G, Moorey H, Kandasami G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Nadeem H, Curtis D, Gurling HM. Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample. Biol Psychiatry. 2006 Jan 15;59(2):195-7.

  115. McQuillin A, Bass NJ, Kalsi G, Lawrence J, Puri V, Choudhury K, Detera-Wadleigh SD, Curtis D, Gurling HM. Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Mol Psychiatry. 2006 Feb;11(2):134-42.

  116. Rizig MA, McQuillin A, Puri V, Choudhury K, Datta S, Thirumalai S, Lawrence J, Quested D, Pimm J, Bass N, Lamb G, Moorey H, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Kandasami G, Curtis D, Gurling H. Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4).

  117. Curtis D, Sham PC. Estimated haplotype counts from case-control samples cannot be treated as observed counts. Am J Hum Genet. 2006 Apr;78(4):729-30; author reply 728-9.

  118. Curtis D, Knight J, Sham PC. Program report: GENECOUNTING support programs. Ann Hum Genet. 2006 Mar;70(Pt 2):277-9.

  119. Gurling HMD, Critchley H, Datta SR, McQuillin A, Blaveri E, Thirumalai S, Pimm J, Krasucki R, Kalsi G, Quested D, Lawrence J, Bass N, Choudhury K, Puri V, O'Daly O, Curtis D, Blackwood D, Muir W, Malhotra AK, Buchanan RW, Good CD, Frackowiak RS, Dolan RJ. Genetic association and brain morphology studies and the chromosome 8p22 gene pericentriolar material 1 (PCM1) in susceptibility to schizophrenia. Arch Gen Psych 2006 63 844-854.

  120. Kalsi G, McQuillin A, Degn B, Lundorf MD, Bass NJ, Lawrence J, Choudhury K, Puri V, Nyegaard M, Curtis D, Mors O, Kruse T, Kerwin S, Gurling H. Identification of the slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24. Am J Psych 2006 163 1767-1776.

  121. North BV, Sham PC, Knight J, Martin ER, Curtis D. Investigation of the ability of haplotype association and logistic regression to identify associated susceptibility loci. Ann Hum Genet. 2006 70 893-906.

  122. Puri V, McQuillin A, Choudhury K, Datta S, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass N, Moorey H, Morgan J, Punukollu B, Kandasami G, Curtis D, Gurling H. Fine Mapping by Genetic Association Implicates the Chromosome 1q23.3 Gene UHMK1, Encoding a Serine/Threonine Protein Kinase, as a Novel Schizophrenia Susceptibility Gene. Biol Psychiatry. 2006 61 873-879.

  123. Choudhury K, McQuillin A, Puri, V, Pimm J, Datta S, Thirumalai S, Krasucki R, Lawrence J, Bass NJ, Crombie C, Fraser G, Walker N, Nadeem H, Johnson S, Curtis D, St Clair D, Gurling HMD. A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia. Am J Hum Genet 2007 80 664-672.

  124. Curtis D, Vine AE, Knight J. A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies. BMC Genetics 2007 8 20.

  125. Curtis D. Allelic association studies of genome wide association data can reveal errors in marker position assignments. BMC Genetics 2007 8 30.

  126. Curtis D. Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association. BMC Genetics 2007 8 49.

  127. Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Pimm J, Bass N, Lamb G, Moorey H, Morgan J, Punukollu B, Kandasami G, Kirwin S, Sule A, Quested D, Curtis D, Gurling HMD. Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia. Behavioral and Brain Functions 2007 3 50.

  128. Curtis D. Extended homozygosity is not usually due to cytogenetic abnormality. BMC Genetics 2007 8 67.

  129. McQuillin A, Bass NJ, Choudhury K, Puri V, Kosmin M, Lawrence J, Curtis D, Gurling HM. Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders. Mol Psychiat 2008.

  130. Curtis D, Vine AE, Knight J. Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations. Ann Hum Genet 2008 72 261-278.

  131. Curtis D, Vine AE, Knight J. A simple approach for assessing the strength of evidence for association at the level of the whole gene. Advances and Applications in Bioinformatics and Chemistry 2008 1 115-120.

  132. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, Macintyre DJ, McLean A, Vanbeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM. Whole-genome association study of bipolar disorder. Mol Psychiatry 2008.

  133. Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary IJ, Harris SE, Isometsä ET, Lawrence J, Lönnqvist J, Muir W, Palotie A, Partonen T, Paunio T, Pylkkö E, Robinson M, Soronen P, Suominen K, Suvisaari J, Thirumalai S, Clair DS, Gurling H, Peltonen L, Porteous D. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry 2008.

  134. Curtis D, Vine AE, Knight J. Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus. Ann Hum Genet 2008.

  135. Knight J, Curtis D, Sham PC. CLUMPHAP: a simple tool for performing haplotype-based association analysis. Genet Epidemiol 2008.

  136. Puri V, McQuillin A, Datta S, Choudhury K, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass N, Crombie C, Fraser G, Walker N, Moorey H, Ray MK, Sule A, Curtis D, Clair DS, Gurling H. Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. Eur J Hum Genet 2008.

  137. Datta SR, McQuillin A, Rizig M, Blaveri E, Thirumalai S, Kalsi G, Lawrence J, Bass NJ, Puri V, Choudhury K, Pimm J, Crombie C, Fraser G, Walker N, Curtis D, Zvelebil M, Pereira A, Kandaswamy R, St Clair D, Gurling HM. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. Mol Psychiatry. 2008

  138. Vine AE, Curtis D. Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium. BMC Res Notes 2009.

  139. Ng MY, Levinson DF, Faraone SV, Suarez BK, Delisi LE, Arinami T, Riley B, Paunio T, Pulver AE, Irmansyah, Holmans PA, Escamilla M, Wildenauer DB, Williams NM, Laurent C, Mowry BJ, Brzustowicz LM, Maziade M, Sklar P, Garver DL, Abecasis GR, Lerer B, Fallin MD, Gurling HM, Gejman PV, Lindholm E, Moises HW, Byerley W, Wijsman EM, Forabosco P, Tsuang MT, Hwu HG, Okazaki Y, Kendler KS, Wormley B, Fanous A, Walsh D, O'Neill FA, Peltonen L, Nestadt G, Lasseter VK, Liang KY, Papadimitriou GM, Dikeos DG, Schwab SG, Owen MJ, O'Donovan MC, Norton N, Hare E, Raventos H, Nicolini H, Albus M, Maier W, Nimgaonkar VL, Terenius L, Mallet J, Jay M, Godard S, Nertney D, Alexander M, Crowe RR, Silverman JM, Bassett AS, Roy MA, Mérette C, Pato CN, Pato MT, Roos JL, Kohn Y, Amann-Zalcenstein D, Kalsi G, McQuillin A, Curtis D, Brynjolfson J, Sigmundsson T, Petursson H, Sanders AR, Duan J, Jazin E, Myles-Worsley M, Karayiorgou M, Lewis CM. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 2008.

  140. Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Robinson M, Lawrence J, Anjorin A, Sklar P, Gurling HM, Curtis D. No evidence for excess runs of homozygosity in bipolar disorder. Psychiatr Genet 2009.

  141. Bass NJ, Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Quested D, Pimm J, Curtis D, Gurling HM. Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. Behav Brain Funct 2009.

  142. Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira AC, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HM, Mortensen PB, Mors O, Børglum AD. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 2009.

  143. Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A, Choudhury K, Datta SR, Puri V, Krasucki R, Pimm J, Thirumalai S, Quested D, Gurling HM. Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes. Psychiatr Genet 2010.

  144. Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary IJ, Harris SE, Isometsä ET, Lawrence J, Lönnqvist J, Muir W, Palotie A, Partonen T, Paunio T, Pylkkö E, Robinson M, Soronen P, Suominen K, Suvisaari J, Thirumalai S, St Clair D, Gurling H, Peltonen L, Porteous D. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry 2009 14 865-73.

  145. Curtis D, Vine AE. Yin yang haplotypes revisited - long, disparate haplotypes observed in European populations in regions of increased homozygosity. Hum Hered 2010 69 184-192.

  146. Pereira AC, McQuillin A, Puri V, Anjorin A, Bass N, Kandaswamy R, Lawrence J, Curtis D, Sklar P, Purcell SM, Gurling HM. Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 2011.

  147. Curtis D. Patient experience - the ingredient missing from cost-effectiveness calculations. Patient Preference and Adherence 2011 5 251-254.

  148. Curtis D. Assessing the Contribution Family Data Can Make to Case-Control Studies of Rare Variants. Ann Hum Genet 2011 5 251-254.

  149. Lydall GJ, Bass NJ, McQuillin A, Lawrence J, Anjorin A, Kandaswamy R, Pereira A, Guerrini I, Curtis D, Vine AE, Sklar P, Purcell SM, Gurling HM. Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. Psychiatr Genet 2011 21 294-306.

  150. Kandaswamy R, McQuillin A, Curtis D, Gurling H. Tests of linkage and allelic association between markers in the 1p36 PRKCZ (Protein Kinase C Zeta) gene region and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 2012 159B 201-9.

  151. Curtis D. A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway. Advances and Applications in Bioinformatics and Chemistry 2012 5 1-9.

  152. Curtis D. Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencing. Psychiatr Genet 2013 23 1-10.

  153. Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, Rujescu D, Werge T, van de Bunt M, Morris AP, McCarthy MI; International Consortium for Blood Pressure GWAS; Diabetes Genetics Replication and Meta-analysis Consortium; Psychiatric Genomics Consortium Schizophrenia Working Group, Roddey JC, McEvoy LK, Desikan RS, Dale AM. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet 2013 92 197-209.

  154. Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI, Ripke S, Santangelo S, Sullivan PF. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013 381:1371-9.
  155. Innes J, Curtis D. Medication patient safety incidents linked to rapid tranquillisation: one year's data from the National Reporting and Learning System. Journal of Psychiatric Intensive Care 2013 11:13-17.
  156. Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013 Aug 11. doi: 10.1038/ng.2711.
  157. Kandaswamy R, McQuillin A, Sharp SI, Fiorentino A, Anjorin A, Blizard RA, Curtis D, Gurling HM. Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder. JAMA Psychiatry 2013 10:1-8.
  158. Curtis D. Approaches to the detection of recessive effects using next generation sequencing data from outbred populations. Adv Appl Bioinform Chem 2013 6:29-35.
  159. Quadri G, McQuillin A, Guerrini I, Thomson AD, Cherian R, Saini J, Ruparelia K, Lydall GJ Ball D, Smith I, Way M, Kasiakogia-Worlley K, Patel S, Kottalgi G, Gunawardena P, Rao H, Hillman A, Douglas E, Qureshi S Y, Reynolds G, Jauhar S, O'Kane A, Sharp S, Kandaswamy R, Dar K, Curtis D, Morgan MY, Gurling HMD. Evidence for genetic susceptibility to the alcohol dependence syndrome from the thiamine transporter 2 gene solute carrier SLC19A3. Psych Genet 2014.
  160. Fiorentino A, O'Brien NL, Locke DP, McQuillin A, Jarram A, Anjorin A, Kandaswamy R, Curtis D, Blizard RA, Gurling HM. Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data. Bipolar Disord 2014 16:583-91.
  161. Kandaswamy R, McQuillin A, Curtis D, Gurling H. Allelic association, DNA resequencing and copy number variation at the metabotropic glutamate receptor GRM7 gene locus in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2014 165B:365-72.
  162. Sharp SI, McQuillin A, Marks M, Hunt SP, Stanford SC, Lydall GJ, Morgan MY, Asherson P, Curtis D, Gurling HM. Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome. Am J Med Genet B Neuropsychiatr Genet 2014 165B:373-80.
  163. O'Brien NL, Way MJ, Kandaswamy R, Fiorentino A, Sharp SI, Quadri G, Alex J, Anjorin A, Ball D, Cherian R, Dar K, Gormez A, Guerrini I, Heydtmann M, Hillman A, Lankappa S, Lydall G, O'Kane A, Patel S, Quested D, Smith I, Thomson AD, Bass NJ, Morgan MY, Curtis D, McQuillin A. The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder. Psychiatr Genet 2014 24:277-8.
  164. Curtis D. OCTET does not demonstrate a lack of effectiveness for community treatment orders. Psychiatr Bull 2014 38:36-9.
  165. Way M, McQuillin A, Saini J, Ruparelia K, Lydall GJ, Guerrini I, Ball D, Smith I, Quadri G, Thomson AD, Kasiakogia-Worlley K, Cherian R, Gunwardena P, Rao H, Kottalgi G, Patel S, Hillman A, Douglas E, Qureshi SY, Reynolds G, Jauhar S, O'Kane A, Dedman A, Sharp S, Kandaswamy R, Dar K, Curtis D, Morgan MY, Gurling HM. Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. Addict Biol 2015 20:594-604.
  166. Curtis D. Investigation of Recessive Effects in Schizophrenia Using Next-Generation Exome Sequence Data. Ann Hum Genet 2015.
  167. Curtis D. Rare missense variants within a single gene form yin yang haplotypes. Eur J Hum Genet 2015.
  168. Lee SH, Byrne EM, Hultman CM, Kähler A, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell T, Gusev A, Hu X, Karlsson R, Mantzioris VX, McGrath JJ, Mehta D, Stahl EA, Zhao Q, Kendler KS, Sullivan PF, Price AL, O'Donovan M, Okada Y, Mowry BJ, Raychaudhuri S, Wray NR; Schizophrenia Working Group of the Psychiatric Genomics Consortium and Rheumatoid Arthritis Consortium. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Int J Epidemiol 2015.
  169. UK10K Consortium, Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JR, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE, Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CM, Timpson NJ, Durbin R, Soranzo N. The UK10K project identifies rare variants in health and disease. Nature 2015 526:82-90.
  170. Huang J, Howie B, McCarthy S, Memari Y, Walter K, Min JL, Danecek P, Malerba G, Trabetti E, Zheng HF; UK10K Consortium, Gambaro G, Richards JB, Durbin R, Timpson NJ, Marchini J, Soranzo N. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nat Commun 2015 6:8111.
  171. Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL; Discovery Biology and Risk of Inherited Variants in Breast Cancer DRIVE study. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am J Hum Genet 2015 97:576-92.
  172. Curtis D, The UK10K Consortium. Practical experience of the application of a weighted burden test to whole exome sequence data for obesity and schizophrenia. Ann Hum Genet 2015.
  173. Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ; Schizophrenia Working Group of Psychiatric Genomics Consortium, de Candia TR, Lee SH, Wray NR, Kendler KS, O'Donovan MC, Neale BM, Patterson N, Price AL. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet 2015.
  174. Bigdeli TB, Ripke S, Bacanu SA, Lee SH, Wray NR, Gejman PV, Rietschel M, Cichon S, St Clair D, Corvin A, Kirov G, McQuillin A, Gurling H, Rujescu D, Andreassen OA, Werge T, Blackwood DH, Pato CN, Pato MT, Malhotra AK, O'Donovan MC, Kendler KS, Fanous AH; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. Am J Med Genet B Neuropsychiatr Genet 2016.
  175. Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA. Schizophrenia risk from complex variation of complement component 4. Nature 2016.
  176. Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Shugart YY, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; ENIGMA Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci 2016.
  177. Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J, Suvisaari J, Chheda H, Blackwood D, Breen G, Pietiläinen O, Gerety SS, Ayub M, Blyth M, Cole T, Collier D, Coomber EL, Craddock N, Daly MJ, Danesh J, DiForti M, Foster A, Freimer NB, Geschwind D, Johnstone M, Joss S, Kirov G, Körkkö J, Kuismin O, Holmans P, Hultman CM, Iyegbe C, Lönnqvist J, Männikkö M, McCarroll SA, McGuffin P, McIntosh AM, McQuillin A, Moilanen JS, Moore C, Murray RM, Newbury-Ecob R, Ouwehand W, Paunio T, Prigmore E, Rees E, Roberts D, Sambrook J, Sklar P, St Clair D, Veijola J, Walters JT, Williams H; Swedish Schizophrenia Study; INTERVAL Study; DDD Study; UK10 K Consortium, Sullivan PF, Hurles ME, O'Donovan MC, Palotie A, Owen MJ, Barrett JC. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nat Neurosci 2016.
  178. Curtis D. Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia. Psychiatr Genet 2016.
  179. Curtis JA, O'Brien NL, Curtis D, Fiorentino A, McQuillin A. Association study of rare nonsynonymous variants of FTO in bipolar disorder. Psychiatr Genet 2016.
  180. Curtis D. Schizophrenia genetics moves into the light. Br J Psychiatry 2016.
  181. Fiorentino A, O'Brien NL, Sharp SI, Curtis D, Bass NJ, McQuillin A. Genetic variation in the miR-708 gene and its binding targets in bipolar disorder. Bipolar Disord 2016.
  182. CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet 2017.
  183. McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nat Commun 2017.
  184. Bipolar Disorders Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Transl Psychiatry 2017.
  185. Singh T, Walters JTR, Johnstone M, Curtis D, Suvisaari J, Torniainen M, Rees E, Iyegbe C, Blackwood D, McIntosh AM, Kirov G, Geschwind D, Murray RM, Di Forti M, Bramon E, Gandal M, Hultman CM, Sklar P; INTERVAL Study; UK10K Consortium, Palotie A, Sullivan PF, O'Donovan MC, Owen MJ, Barrett JC. The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nat Genet 2017.
  186. Leonenko G, Richards AL, Walters JT, Pocklington A, Chambert K, Al Eissa MM, Sharp SI, O'Brien NL, Curtis D, Bass NJ, McQuillin A, Hultman C, Moran JL, McCarroll SA, Sklar P, Neale BM, Holmans PA, Owen MJ, Sullivan PF, O'Donovan MC. Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2017.
  187. Curtis D, Emmett W. Association study of schizophrenia with variants in miR-137 binding sites. Schizophr Res 2017.
  188. Curtis D. Letter to the Editor: Association between smoking and psychosis may be mediated by maternal smoking during pregnancy. Psychol Med 2018.
  189. Curtis D, Derks EM. Letter to the Editor: Schizophrenia does not represent the extreme of a normally distributed trait. Psychol Med 2018.
  190. Curtis D. Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test. Ann Hum Genet 2018.
  191. Al Eissa MM, Fiorentino A, Sharp SI, O'Brien NL, Wolfe K, Giaroli G, Curtis D, Bass NJ, McQuillin A. Exome sequence analysis and follow up genotyping implicates rare ULK1 variants to be involved in susceptibility to schizophrenia. Ann Hum Genet 2018.
  192. O'Brien NL, Fiorentino A, Curtis D, Rayner C, Petrosellini C, Al Eissa M, Bass NJ, McQuillin A, Sharp SI. Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITGΒ4 gene in schizophrenia and bipolar disorder. Schizophr Res 2018.
  193. Curtis D, Coelewij L, Liu SH, Humphrey J, Mott R. Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology. Behav Genet 2018.
  194. Curtis D. Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets. Psychiatr Genet 2018.
  195. Gupta S, Akyuz EU, Baldwin T, Curtis D. Community treatment orders in England: review of usage from national data. BJPsych Bull 2018.
  196. Ni G, Moser G; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Wray NR, Lee SH. Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. Am J Hum Genet 2018.
  197. Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell 2018.
  198. Coelewij L, Curtis D. Mini-review: Update on the genetics of schizophrenia. Ann Hum Genet 2018.
  199. Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science 2018.
  200. Ni G, Gratten J, Wray NR, Lee SH; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Age at first birth in women is genetically associated with increased risk of schizophrenia. Sci Rep 2018.
  201. Curtis D. Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia. Psychiatr Genet 2018.
  202. Curtis D. A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score. Eur J Hum Genet 2018.
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